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I am one of the 35,000,000 Americans who suffer from chronic sinusitis. I've looked at numerous potential sinusitis cures over the years and have undergone two painful sinus operations. I still was coming down with sinus infections after that, which was pretty discouraging, and I had to make lifestyle changes I wasn't pleased with. Over the past four years or so I've found help using pulsating nasal irrigation with a saline solution, and the situation is relatively 'under control'. I still get clogged up most nights, however, and have to take several medications, including a steroid spray.

Research has been done by the Mayo Clinic in the hope of finding new sinusitis cures. I've been in touch with one of the physicians on the Mayo Clinic research team who advised me that there is a new therapy which may actually treat the root cause of chronic sinusitis in many people. In this article I'll summarize in layman's terms the results of the research.

The research showed that people with chronic sinusitis have a different immune response in their nasal cavities to naturally occurring fungi, which they showed is present in the nasal cavities of almost everyone. The research team was able to demonstrate that in some people (chronic sinusitis sufferers) certain white blood cells, known as eosinophites, activate and thereby produce a chemical, called MBP, which causes damage to nasal membranes. Bacteria can then invade the damaged areas and cause sinus infections. It therefore made sense that an option in the search for new sinusitis cures would be to treat the fungus rather than treat the bacteria with an antibiotic, which is often the therapy followed conventionally.

Mayo Clinic studies have shown that 75% of chronic sinusitis sufferers saw improvement when treated with a topical fungicide. The Therapy is called topical antifungal therapy. An antifungal called Amphotericin B has already been approved by the FDA for other treatments and is normally administered to patients as an injection. For sinusitis cures it is made into a topical nasal spray and applied daily. The recommended dose is 100 micrograms/ml. This medication is generally not available in most pharmacies today. One must get the prescription filled through a compounding pharmacy such as Anazao.

The best thing to do is find a physician who is trained in administering this therapy, and that doctor can no doubt explain how to obtain the medication prescribed.

In some people the eosinophiles do not react to fungi present in the nasal mucus, and these people generally do not have chronic sinusitis. Why the eosinophiles act differently in different people is not yet known. Also, it is difficult to administer a test which will tell if one person has this type of reaction occur in his body or not. However, this theory would explain why some people are chronic sinusitis sufferers even after extensive conventional treatments or sinus operations. The conventional therapies and surgeries to date have simply not addressed this issue, since it was not known prior to the Mayo Clinic studies and patient tests.

Chronic sinusitis sufferers should be aware that this new therapy is available today in some locations, that it is gaining popularity, and it is becoming part of the arsenal of sinusitis cures available. People desperate for help should try to locate a physician who has been trained to administer this treatment and determine if it would help in their case. If you cannot locate such treatment in your area, please go to http://www.postnasaldrip.net and click the Contact Us button and we'll try to help, but travel may be required.